Something new

A genetic study in Nature Human Behaviour suggests that loneliness may not be a direct cause of disease, but the findings indicate that managing risk factors related to loneliness could still improve long-term health outcomes. Read the article: https://go.nature.com/3Xn2Y4m

Regions of the human brain may shrink in size during pregnancy, but have better connectivity, with only a few regions of the brain remaining untouched by the transition to motherhood. Read the paper: https://go.nature.com/4erhyPi

Adults with overweight or obesity who exercise regularly for at least two years exhibit distinct structural and proteomic characteristics in abdominal subcutaneous adipose tissue that may contribute to better cardiometabolic health outcomes. Read the paper: https://go.nature.com/3Zlb00k 🔒

A study in Nature identifies a brain network observed to be nearly two times larger in most sampled individuals with depression than in healthy counterparts. The findings highlight new potential targets for future therapeutic interventions. Read the paper: https://go.nature.com/3ZbVdAX

A study in Nature reports that immune responses in trans men (assigned female at birth) during gender-affirming hormone therapy become more like those of cisgender male individuals. Read the paper: https://go.nature.com/3z43A6W

A study in Nature Communications develops a high-throughput deep-phenotyping approach to evaluate circadian rhythms and use it to determine time-of-day drug sensitivity in cancer cell lines. Read the paper: https://go.nature.com/478n8nl

A Review in Nature Metabolism provides an overview of the interplay between diet and the gut microbiota, and how this affects brain function. Read the Review: https://go.nature.com/3Mr32ec

A study in Nature Human Behaviour finds that non-cognitive skills increasingly predict academic achievement over development, driven by shared genetic factors whose influence grows over school years. These effects persist across socio-economic contexts and suggest the importance of fostering non-cognitive skills in education. Read the article: https://go.nature.com/4cJHx3e

A Review in Nature Reviews Endocrinology discusses the current understanding of the concept of metabolically healthy obesity (MHO), the challenges in defining MHO and how the concept can be used to improve the prevention and treatment of cardiometabolic disease. Read the Review: https://go.nature.com/470isjl 🔒

Platelet hyperreactivity is associated with cardiovascular events in patients with peripheral artery disease. A study in Nature Communications derives and validates a circulating platelet genetic signature to discriminate platelet hyperreactivity and cardiovascular risk. Read the paper: https://go.nature.com/3MhlCFz

Deep brain stimulation that uses personalised neural signals could help reduce the duration of motor symptoms by 50% in people with Parkinson’s disease, relative to the use of conventional devices, according to a small clinical trial reported in Nature Medicine. Read the paper: https://go.nature.com/3MbfnDp

A study published in Nature Aging reports that the molecular changes during aging are nonlinear with two major waves of age-related changes at approximately 44 years and 60 years of age. Read the paper: https://go.nature.com/4cwBH4W

A paper published in Nature Medicine demonstrates that proteomic aging can be used to predict age-related functional status, multimorbidity and mortality risk across geographically and genetically diverse populations. Read the paper: https://go.nature.com/3SNSZDR

Whole-genome sequencing of more than 2,000 colorectal carcinoma samples provides a highly detailed view of the genomic landscape of colorectal cancer and identifies new driver mutations. Read the paper: https://go.nature.com/3yvCnK4

A Review in Nature Medicine outlines how Western-style diets contribute to the rising incidence of chronic, noncommunicable diseases by converging on key mechanisms, including gut microbial rarefaction and chronic inflammation. Read the Review: https://go.nature.com/3WK0DkO 🔒